PMR Provides a Detailed Market Study on Venous Thromboembolism Treatment Based on Current Availability of Drugs, R&D of Novel Drugs, and a Growing Impact of Digitalization
Industry: Healthcare
Format: PPT*, PDF, EXCEL
Delivery Timelines: Contact Sales
Report Type: Ongoing
Report ID: PMRREP34599
The global venous thromboembolism treatment market is estimated to value at US$2.9 Bn by the end of 2031 from US$2.2 Bn estimated in 2024. the market is expected to secure a CAGR of 4.2% in the forthcoming years from 2024 to 2031.
Key Highlights of the Market
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Market Attributes |
Key Insights |
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Market Size (2024E) |
US$2.2 Bn |
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Projected Market Value (2031F) |
US$2.9 Bn |
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Forecast Growth Rate (CAGR 2024 to 2031) |
4.2% |
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Historical Growth Rate (CAGR 2018 to 2023) |
3.6% |
Venous thromboembolism (VTE), encompassing both deep vein thrombosis (DVT) and pulmonary embolism (PE), presents a significant global health challenge, affecting millions of individuals annually.
DVT occurs when a blood clot forms in a deep vein, typically in the legs, while PE arises when such a clot dislodges and travels to the lungs, causing potentially life-threatening complications.
The increasing prevalence of VTE, driven by factors such as aging populations, sedentary lifestyles, and rising incidences of chronic diseases, underscores the urgent need for effective treatment strategies.
The VTE treatment market is characterized by a dynamic landscape, with continuous advancements in pharmacotherapy playing a central role.
Traditionally, treatment options have included anticoagulants like heparin and vitamin K antagonists (VKAs), such as warfarin.
However, the market has witnessed a paradigm shift with the advent of direct oral anticoagulants (DOACs), including agents like rivaroxaban, apixaban, edoxaban, and dabigatran.
These DOACs offer significant advantages over conventional therapies, such as fixed dosing without the need for routine coagulation monitoring, fewer dietary restrictions, and a lower risk of major bleeding.
Despite these advancements, the market faces challenges, including high treatment costs and potential side effects of anticoagulants, which can limit patient adherence and outcomes.
Addressing these issues through innovative solutions and comprehensive healthcare strategies remains essential for the sustained development of the VTE treatment market.
The venous thromboembolism (VTE) treatment market has experienced significant evolution over the past few decades, driven by advances in medical research, increased awareness, and improved diagnostic and therapeutic options.
Initially, the treatment landscape was dominated by heparin, and warfarin. Heparin, an injectable anticoagulant, was widely used for its immediate action, while VKAs like warfarin were employed for long-term management.
These treatments, though effective, required frequent monitoring and had significant dietary and drug interaction issues.
The introduction of LMWHs, such as enoxaparin, offered advantages over unfractionated heparin, including more predictable pharmacokinetics, reduced need for monitoring, and easier administration.
The future of the VTE treatment market looks promising, with several trends and developments poised to shape its trajectory.
Research and development efforts are focused on creating next-generation anticoagulants with improved safety profiles, fewer side effects, and enhanced efficacy.
These innovations aim to further reduce bleeding risks and offer better outcomes for diverse patient populations.
Advances in genomics and precision medicine are paving the way for personalized anticoagulation therapies.
Understanding individual genetic and metabolic profiles can help optimize treatment regimens, minimizing adverse effects and maximizing therapeutic benefits.
VTE treatment market has made substantial progress historically, and the course ahead promises further advancements in therapeutic options, personalized care, and digital health integration.
These developments, coupled with ongoing efforts to reduce costs and enhance access, are set to transform the landscape of VTE management, ultimately improving patient outcomes and quality of life.
The Rise of Advanced Diagnostic Techniques
Advanced diagnostic techniques are significantly driving the growth of the Venous Thromboembolism (VTE) treatment market.
With the advent of highly sophisticated diagnostic tools such as Doppler ultrasound and D-dimer tests, the early and accurate detection of VTE has become more achievable.
Such technologies allow healthcare professionals to identify blood clots at their inception, facilitating prompt and effective intervention.
The precision and reliability of these advanced diagnostics not only improve patient outcomes but also increase the demand for VTE treatment options.
Moreover, these techniques reduce the likelihood of misdiagnosis and subsequent complications, thus enhancing overall patient care and fostering confidence in VTE management among healthcare providers.
Public Awareness, and Preventive Measures
Public awareness and preventive measures are critical drivers of the VTE treatment market.
Campaigns like the Stop the Clot, Spread the Word® initiative, developed by the National Blood Clot Alliance in collaboration with the CDC, play a pivotal role in educating the public about the risks, signs, and symptoms of blood clots.
These campaigns disseminate vital information through various multimedia resources, targeting high-risk groups such as recently hospitalized patients, pregnant women, and cancer patients.
By increasing awareness and promoting early detection, these initiatives help in preventing serious complications associated with VTE.
The emphasis on public education not only boosts demand for preventive treatments, such as anticoagulants and compression devices but also encourages early intervention, leading to better patient outcomes.
Side Effects of Anticoagulants
A primary concern with anticoagulant therapy is the risk of excessive bleeding (hemorrhage), as these medications extend the time it takes for blood clots to form.
Symptoms of excessive bleeding can include passing blood in urine or stools, severe bruising, prolonged nosebleeds, vomiting or coughing up blood, sudden severe back pain, difficulty breathing, and in women, heavy menstrual bleeding or unusual vaginal bleeding.
Such side effects necessitate immediate medical attention and can deter patients from adhering to prescribed anticoagulant regimens.
Furthermore, individuals on warfarin require regular blood tests to monitor clotting times, adjusting doses accordingly to minimize bleeding risks.
Other side effects, which vary by specific medication, can include gastrointestinal issues like diarrhea, nausea, indigestion, dizziness, headaches, skin rashes, itching, hair loss, and jaundice.
The potential for these adverse effects often limits the use of anticoagulants, thereby restraining the growth of the VTE treatment market.
Towering Treatment Costs
A comprehensive review of economic burden studies reveals that the initial costs of treating VTE range from approximately $3,000 to $9,500 in the US.
Over time, these costs escalate, with total expenditures reaching around $5,000 over three months, $10,000 over six months, and $33,000 over one year.
European studies also report substantial additional inpatient costs, amounting to €1,800 after three months and €3,200 after one year.
Furthermore, complications associated with VTE, such as post-thrombotic syndrome and heparin-induced thrombocytopenia, add significant financial burdens, with treatment costs ranging from US$426 to US$11,700 and US$3,118 to $41,133, respectively.
These high treatment costs, exacerbated by the frequent and costly complications, strain healthcare systems and deter optimal treatment adherence, thereby restraining the growth and accessibility of the VTE treatment market.
Evolution of Novel Drugs for Venous Thromboembolism
Over the past 15 years, the introduction of direct oral anticoagulants (DOACs) has revolutionized anticoagulant therapy for VTE, simplifying treatment protocols and improving patient outcomes.
Agents such as apixaban, edoxaban, and rivaroxaban, which inhibit factor Xa, and dabigatran, which inhibits thrombin, have largely supplanted traditional therapies like low-molecular-weight heparin and vitamin K antagonists (VKAs) such as warfarin.
These DOACs have become the preferred choice for thromboprophylaxis following elective hip or knee arthroplasty and for the prevention of VTE recurrence in patients without active cancer, due to their comparable efficacy and significantly lower risk of major bleeding.
Additionally, DOACs offer greater convenience with fixed dosing, no need for coagulation monitoring, fewer dietary and drug interactions, and the option for all-oral regimens that streamline the transition from hospital to home care.
For cancer-associated VTE, DOACs have shown effectiveness comparable to dalteparin, further expanding their use.
The continuous development and refinement of anticoagulant therapies underscore the dynamic nature of the VTE treatment market, fostering ongoing improvements in patient care and outcomes.
Regulatory Approvals for New and Existing VTE Treatments
The recent approval by the U.S. Food and Drug Administration (FDA) of two pediatric indications for XARELTO® (rivaroxaban), a direct oral anticoagulant (DOAC) developed by the Janssen Pharmaceutical Companies of Johnson & Johnson, marks a significant milestone.
XARELTO® is now FDA-approved for the treatment of VTE and the reduction of recurrent VTE risk in patients from birth to less than 18 years, following at least five days of initial parenteral anticoagulant treatment.
Additionally, it is approved for thromboprophylaxis in children aged two years and older with congenital heart disease who have undergone the Fontan procedure.
This approval makes XARELTO® the only DOAC authorized for primary prevention of clots in pediatric patients post-Fontan procedure, and it offers an oral suspension formulation for flexible, body weight-adjusted dosing.
This development addresses a significant gap in pediatric VTE treatment, where existing therapies like warfarin and heparin require painful injections, dietary restrictions, and frequent monitoring, often with adjusted adult dosages based on limited pediatric data.
The FDA's endorsement of XARELTO® for pediatric use, including its tailored dosing options, represents a major advancement in antithrombotic care, providing a more convenient and effective treatment alternative for young patients at risk of serious blood clots.
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Category |
Projected CAGR through 2031 |
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Drug Type Category - Anticoagulants |
5.0% |
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Route of Administration - Oral |
4.6% |
Anticoagulants to Account for a Significant Share
Anticoagulants encompass a range of therapies including direct oral anticoagulants (DOACs) such as rivaroxaban, apixaban, and dabigatran, as well as traditional therapies like heparins and vitamin K antagonists (VKAs) such as warfarin.
These medications work by inhibiting clot formation or promoting clot dissolution, thereby reducing the risk of deep vein thrombosis (DVT), pulmonary embolism (PE), and associated complications.
The shift towards DOACs, characterized by their ease of use with fixed dosing regimens and minimal need for monitoring compared to VKAs, has significantly bolstered the growth of the anticoagulants segment.
Moreover, advancements in oral formulations and the FDA approvals for pediatric use of medications like rivaroxaban further underscore the expanding scope of anticoagulants in addressing thrombotic disorders across diverse patient populations.
As healthcare providers continue to prioritize effective, convenient, and safer treatment options, the anticoagulants segment is poised to maintain its prominent position in the VTE treatment market.
Oral Administration Continues to Gain Preference
The oral route of administration is increasingly prominent in the treatment landscape for Venous Thromboembolism (VTE), driven by the evolution of Direct Oral Anticoagulants (DOACs) like rivaroxaban and apixaban.
These medications have revolutionized VTE management by offering fixed dosing, rapid onset of action, and eliminating the need for regular coagulation monitoring, which were drawbacks of traditional injectable therapies.
This transition to oral formulations enhances patient convenience, supports effective outpatient care, and promotes better treatment adherence across diverse patient demographics, including pediatric populations.
As regulatory approvals expand and research continues to refine these therapies, the oral route is set to play an increasingly pivotal role in improving outcomes and quality of life for VTE patients worldwide.
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Region |
CAGR through 2034 |
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North America |
4.1% |
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Asia Pacific |
5.9% |
North America’s Leading Position Intact
North America is set to hold a significant share in the venous thromboembolism treatment market, driven by factors such as advanced healthcare infrastructure, high healthcare expenditure, and a large population at risk for VTE.
The region's proactive adoption of new treatments like DOACs, and its supportive regulatory environment contribute to its leadership in improving VTE management outcomes.
These factors position North America as a key player in driving innovation and advancements in VTE treatment.
Asia Pacific to Exhibit a Notable CAGR Through 2031
Asia Pacific is expected to exhibit a notable CAGR in the VTE treatment market. This growth can be attributed to several factors, including rising awareness about VTE, increasing prevalence of risk factors such as diabetes and cardiovascular diseases, and improvements in healthcare infrastructure across the region.
Government initiatives aimed at enhancing healthcare access and affordability, along with expanding healthcare insurance coverage, are also contributing to market growth.
Moreover, advancements in healthcare technology and increasing investments by pharmaceutical companies in the region are further fueling the adoption of VTE treatments.
Acquisitions, partnerships, and innovative product development are pivotal strategies driving growth in the Venous Thromboembolism (VTE) treatment market.
Key innovations include advanced anticoagulant therapies like DOACs, personalized medicine approaches, and integration of digital health technologies for remote monitoring and treatment optimization.
These efforts aim to enhance treatment efficacy, safety, and patient outcomes worldwide.
June 2024
Royal Philips announced the first implant of the Duo Venous Stent System, an implantable medical device indicated to treat symptomatic venous outflow obstruction in patients with chronic venous insufficiency (CVI), following premarket approval (PMA) from the U.S. Food and Drug Association (FDA).
June 2024
Alembic Pharmaceuticals has received final approval from U.S. Food and Drug Administration for its abbreviated new drug application for Dabigatran Etexilate Capsules, 75 mg and 150 mg and tentative approval for Dabigatran Etexilate Capsules, 110 mg.
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Attributes |
Details |
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Forecast Period |
2024 to 2031 |
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Historical Data Available for |
2018 to 2023 |
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Market Analysis |
US$ Billion for Value |
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Key Regions Covered |
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Key Market Segments Covered |
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Key Companies Profiled in the Report |
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Report Coverage |
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Customization & Pricing |
Available upon request |
By Drug Type
By Route of Administration
By Region
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The main treatments include anticoagulant medications (such as heparin and warfarin), and newer Direct Oral Anticoagulants (DOACs) like rivaroxaban and apixaban, which simplify treatment with fixed dosing and minimal monitoring requirements.
Factors driving market growth include increasing awareness, advancements in treatment options, rising prevalence of risk factors, and supportive healthcare policies.
Innovations include personalized medicine approaches, advancements in diagnostic techniques, and ongoing research into new anticoagulant therapies.
Future trends include continued technological advancements, and the increased regulatory focus.
North America to account for the significant share in the market.
